SAG-524 is an orally active HBV viral replication inhibitor. SAG-524 selectively modulates PAPD5 to destabilize HBV-RNA by shortening its poly(A) tail. SAG-524 reduces levels of HBV-DNA, HBsAg, and HBcrAg, and reduces intrahepatic cccDNA in HBV-infected mice models. SAG-524 shows no significant toxicity and neurotoxicity in mice and monkeys. SAG-524 can be used for the research of hepatitis b virus (HBV) infection[1].
Molecular Weight:
594.12
Purity:
98.50
CAS Number:
[2246696-89-7]
Formula:
C30H32ClN5O4S
Target:
HBV
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
