FTI 276 is a farnesyltransferase (FTase) inhibitor with an IC50 of 0.5 nM, and it exhibits selectivity for FTase over geranylgeranyltransferase I (GGTase I). FTI 276 blocks the farnesylation of H-Ras and K-Ras4B, causes inactive Ras-Raf complexes to accumulate in the cytoplasm, and inhibits constitutive MAPK activation. FTI 276 reduces the number, incidence and volume of tumors, and restricts the growth of tumors expressing activated K-ras. FTI 276 can be used in research related to pulmonary adenoma[1][2].
Molekulargewicht:
433.59
CAS Nummer:
[170006-72-1]
Formel:
C21H27N3O3S2
Target-Kategorie:
Farnesyl Transferase,p38 MAPK,Ras
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
