FTI 276 is a farnesyltransferase (FTase) inhibitor with an IC50 of 0.5 nM, and it exhibits selectivity for FTase over geranylgeranyltransferase I (GGTase I). FTI 276 blocks the farnesylation of H-Ras and K-Ras4B, causes inactive Ras-Raf complexes to accumulate in the cytoplasm, and inhibits constitutive MAPK activation. FTI 276 reduces the number, incidence and volume of tumors, and restricts the growth of tumors expressing activated K-ras. FTI 276 can be used in research related to pulmonary adenoma[1][2].
Molecular Weight:
433.59
CAS Number:
[170006-72-1]
Formula:
C21H27N3O3S2
Target:
Farnesyl Transferase,p38 MAPK,Ras
Application Notes:
MCE Product type: Reference compound
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