Glu-AMS is a competitive inhibitor of Escherichia coli glutamyl-tRNA synthetase (GluRS) with a Ki of 2.8 nM, and it shows weak binding ability to free GluRS. The binding affinity of Glu-AMS for GluRS increases in the presence of cognate tRNAGlu, while no change in affinity occurs in the presence of non-cognate tRNAPhe. Glu-AMS facilitates in-depth understanding of the evolutionary mechanism of GluRS: glutamate is activated only in the presence of tRNAGlu, thus avoiding futile ATP cleavage[1].
Molekulargewicht:
475.43
CAS Nummer:
[859213-87-9]
Formel:
C15H21N7O9S
Target-Kategorie:
Aminoacyl-tRNA Synthetase,Bacterial
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
