NR-V04 is a selective NR4A1 PROTAC degrader. NR-V04 forms a ternary complex with NR4A1 and the VHL E3 ligase, mediates proteasome-dependent degradation of NR4A1. NR-V04 induces tumor-infiltrating B cells and effector memory CD8+ T cells and reduces monocytic myeloid-derived suppressor cells in tumor microenvironments. NR-V04 can be used for the research of melanoma and colon cancer[1].
Molekulargewicht:
1110.45
Reinheit:
96.71
CAS Nummer:
[2766608-52-8]
Formel:
C62H87N5O11S
Target-Kategorie:
Nuclear Hormone Receptor 4A/NR4A,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
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