NR-V04 is a selective NR4A1 PROTAC degrader. NR-V04 forms a ternary complex with NR4A1 and the VHL E3 ligase, mediates proteasome-dependent degradation of NR4A1. NR-V04 induces tumor-infiltrating B cells and effector memory CD8+ T cells and reduces monocytic myeloid-derived suppressor cells in tumor microenvironments. NR-V04 can be used for the research of melanoma and colon cancer[1].
Molecular Weight:
1110.45
Purity:
96.71
CAS Number:
[2766608-52-8]
Formula:
C62H87N5O11S
Target:
Nuclear Hormone Receptor 4A/NR4A,PROTACs
Application Notes:
MCE Product type: Reference compound
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