HPK1-IN-54, CAS [[3048537-48-7]] Preis auf Anfrage

Produktübersicht

• Artikelname: HPK1-IN-54, CAS [[3048537-48-7]] Preis auf Anfrage
• Artikelnummer: MCE-HY-159905
• Hersteller Artikelnummer: HY-159905
• Alternativnummer: MCE-HY-159905-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

HPK1-IN-54 is a potent HPK1 (Hematopoietic Progenitor Kinase 1) inhibitor that enhances T cell activation and proliferation by inhibiting HPK1 activity, thereby exhibiting antitumor effects. Its IC50 value against HPK1 is 2.67 nM, with excellent selectivity over the MAP4K family (>100-fold) and other selected kinases (>300-fold). HPK1-IN-54 displayed moderate in vivo clearance and reasonable oral exposure in mice and rats. Additionally, HPK1-IN-54 demonstrated strong antitumor efficacy in a CT26 murine colon cancer model and synergistic effects when combined with anti-PD-1 (HY-P9902A). HPK1-IN-54 shows promise for research in the field of immunotherapy[1].

Produkteigenschaften

• Molekulargewicht: 583.66
• CAS Nummer: [3048537-48-7]
• Formel: C32H34FN7O3
• Target-Kategorie: MAP4K

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound