HPK1-IN-54, CAS [[3048537-48-7]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-159905
Supplier Catalog Number:
HY-159905
Alternative Catalog Number:
MCE-HY-159905-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
HPK1-IN-54 is a potent HPK1 (Hematopoietic Progenitor Kinase 1) inhibitor that enhances T cell activation and proliferation by inhibiting HPK1 activity, thereby exhibiting antitumor effects. Its IC50 value against HPK1 is 2.67 nM, with excellent selectivity over the MAP4K family (>100-fold) and other selected kinases (>300-fold). HPK1-IN-54 displayed moderate in vivo clearance and reasonable oral exposure in mice and rats. Additionally, HPK1-IN-54 demonstrated strong antitumor efficacy in a CT26 murine colon cancer model and synergistic effects when combined with anti-PD-1 (HY-P9902A). HPK1-IN-54 shows promise for research in the field of immunotherapy[1].
Molecular Weight:
583.66
CAS Number:
[3048537-48-7]
Formula:
C32H34FN7O3
Target:
MAP4K
Application Notes:
MCE Product type: Reference compound
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