pan-TEAD-IN-1, CAS [[3027484-09-6]] Preis auf Anfrage

Produktübersicht

• Artikelname: pan-TEAD-IN-1, CAS [[3027484-09-6]] Preis auf Anfrage
• Artikelnummer: MCE-HY-159912
• Hersteller Artikelnummer: HY-159912
• Alternativnummer: MCE-HY-159912-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

pan-TEAD-IN-1 (Compound 3) is an orally active pan-TEAD inhibitor targeting the palmitoylation site of TEAD, disrupting its interaction with the coactivators YAP/TAZ, thereby suppressing the transcriptional upregulation of oncogenes (e.g., Ctgf and Cyr61) in the Hippo signaling pathway. pan-TEAD-IN-1 exhibits excellent activity with a luciferase IC50 of 0.36 nM and an H226 cell IC50 of 1.52 nM. It also shows favorable pharmacokinetics (AUC0-° = 228.7 µg/mLmin, T1/2 = 183.9 min). In TEAD-dependent xenograft mouse models, pan-TEAD-IN-1 significantly inhibited tumor growth, showing promise for research in TEAD-dependent cancers[1].

Produkteigenschaften

• Molekulargewicht: 331.33
• CAS Nummer: [3027484-09-6]
• Formel: C19H16F3NO
• Target-Kategorie: YAP

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound