pan-TEAD-IN-1, CAS [[3027484-09-6]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-159912
Supplier Catalog Number:
HY-159912
Alternative Catalog Number:
MCE-HY-159912-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
pan-TEAD-IN-1 (Compound 3) is an orally active pan-TEAD inhibitor targeting the palmitoylation site of TEAD, disrupting its interaction with the coactivators YAP/TAZ, thereby suppressing the transcriptional upregulation of oncogenes (e.g., Ctgf and Cyr61) in the Hippo signaling pathway. pan-TEAD-IN-1 exhibits excellent activity with a luciferase IC50 of 0.36 nM and an H226 cell IC50 of 1.52 nM. It also shows favorable pharmacokinetics (AUC0-° = 228.7 µg/mLmin, T1/2 = 183.9 min). In TEAD-dependent xenograft mouse models, pan-TEAD-IN-1 significantly inhibited tumor growth, showing promise for research in TEAD-dependent cancers[1].
Molecular Weight:
331.33
CAS Number:
[3027484-09-6]
Formula:
C19H16F3NO
Target:
YAP
Application Notes:
MCE Product type: Reference compound
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