Top/HDAC-IN-3, CAS [[3059615-90-3]] Preis auf Anfrage
Artikelnummer:
MCE-HY-159966
Hersteller Artikelnummer:
HY-159966
Alternativnummer:
MCE-HY-159966-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
Top/HDAC-IN-3 (Compound 31) is an orally active dual inhibitor of Topoisomerase and HDAC. Top/HDAC-IN-3 increases reactive oxygen species (ROS) levels, leading to DNA damage, thereby inhibiting cancer cell colony formation and migration, inducing cancer cell Apoptosis, and causing cell cycle arrest. In the NSCLC model, Top/HDAC-IN-3 exhibited significant antitumor effects, with a tumor growth inhibition (TGI) of 77.5% at 100 mg/kg, surpassing the efficacy of the HDAC inhibitor SAHA (HY-10221) and the combination of SAHA (HY-10221) with the topoisomerase inhibitor Irinotecan (HY-16562)[1].
Molekulargewicht:
435.47
CAS Nummer:
[3059615-90-3]
Formel:
C24H25N3O5
Target-Kategorie:
Apoptosis,HDAC,Reactive Oxygen Species (ROS),Topoisomerase
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
