Top/HDAC-IN-3, CAS [[3059615-90-3]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-159966
Supplier Catalog Number:
HY-159966
Alternative Catalog Number:
MCE-HY-159966-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Top/HDAC-IN-3 (Compound 31) is an orally active dual inhibitor of Topoisomerase and HDAC. Top/HDAC-IN-3 increases reactive oxygen species (ROS) levels, leading to DNA damage, thereby inhibiting cancer cell colony formation and migration, inducing cancer cell Apoptosis, and causing cell cycle arrest. In the NSCLC model, Top/HDAC-IN-3 exhibited significant antitumor effects, with a tumor growth inhibition (TGI) of 77.5% at 100 mg/kg, surpassing the efficacy of the HDAC inhibitor SAHA (HY-10221) and the combination of SAHA (HY-10221) with the topoisomerase inhibitor Irinotecan (HY-16562)[1].
Molecular Weight:
435.47
CAS Number:
[3059615-90-3]
Formula:
C24H25N3O5
Target:
Apoptosis,HDAC,Reactive Oxygen Species (ROS),Topoisomerase
Application Notes:
MCE Product type: Reference compound
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