VNPP433-3beta (Galeterone 3beta-imidazole) is an orally active molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2. VNPP433-3beta induces cell apoptosis. VNPP433-3beta inhibits tumor growth in the CWR22Rv1 xenograft mouse model. VNPP433-3beta can be used for the study of castration resistant prostate cancer (CRPC) and pancreatic ductal adenocarcinoma (PDAC)[1].
Molekulargewicht:
438.61
Reinheit:
98.01
CAS Nummer:
[1630820-51-7]
Formel:
C29H34N4
Target-Kategorie:
Androgen Receptor,Apoptosis,MNK,Molecular Glues
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten