GDC-3280 (AK3287, AKEX0011) is an orally active compound based on Pirfenidone (HY-B0673)s phenyl pyridone scaffold. GDC-3280 alleviates the inflammatory and fibrotic reaction of silicosis by inhibiting the ASK1-p38 MAPK pathway and regulating macrophage polarization. GDC-3280 exhibits anti-inflammatory and anti-fibrotic effects[1].
Molekulargewicht:
389.33
Reinheit:
98.82
CAS Nummer:
[1590403-33-0]
Formel:
C18H14F3N5O2
Target-Kategorie:
ASK1,p38 MAPK
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten