GDC-3280 (AK3287, AKEX0011) is an orally active compound based on Pirfenidone (HY-B0673)s phenyl pyridone scaffold. GDC-3280 alleviates the inflammatory and fibrotic reaction of silicosis by inhibiting the ASK1-p38 MAPK pathway and regulating macrophage polarization. GDC-3280 exhibits anti-inflammatory and anti-fibrotic effects[1].
Molecular Weight:
389.33
Purity:
98.82
CAS Number:
[1590403-33-0]
Formula:
C18H14F3N5O2
Target:
ASK1,p38 MAPK
Application Notes:
MCE Product type: Reference compound
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