JTT-654 is an orally active, potent and selective11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor. The IC50 of JTT-654 for 11beta-HSD1 is 4.65, 0.97, and 0.74 nM in human, rat, and mouse recombinant enzymes, respectively. JTT-654 showed competitive inhibition against human recombinant enzyme. The IC50 value for human 11beta-HSD2 is > 30 µM (human 11beta-HSD2 is responsible for the reverse reaction against human 11beta-HSD1). JTT-654 ameliorates insulin resistance and non-obese type 2 diabetes by inhibiting adipose tissue and liver 11beta-HSD1[1][2].
Molekulargewicht:
530.58
CAS Nummer:
[916828-66-5]
Formel:
C28H33F3N4O3
Target-Kategorie:
11beta-HSD
Anwendungsbeschreibung:
MCE Product type: Reference compound
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