JTT-654 is an orally active, potent and selective11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor. The IC50 of JTT-654 for 11beta-HSD1 is 4.65, 0.97, and 0.74 nM in human, rat, and mouse recombinant enzymes, respectively. JTT-654 showed competitive inhibition against human recombinant enzyme. The IC50 value for human 11beta-HSD2 is > 30 µM (human 11beta-HSD2 is responsible for the reverse reaction against human 11beta-HSD1). JTT-654 ameliorates insulin resistance and non-obese type 2 diabetes by inhibiting adipose tissue and liver 11beta-HSD1[1][2].
Molecular Weight:
530.58
CAS Number:
[916828-66-5]
Formula:
C28H33F3N4O3
Target:
11beta-HSD
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
