PHGDH-IN-5 (Compound B12) is a covalen inhibitor of PHGDH with an IC50 value of 0.29 µM. PHGDH-IN-5 can inhibit cell proliferation in cancer cell lines overexpressing PHGDH. PHGDH-IN-5 can reduce the production of serine derived from glucose in MDA-MB-468 cells[1].
Molekulargewicht:
211.19
Reinheit:
98.12
CAS Nummer:
[17402-86-7]
Formel:
C8H5NO4S
Target-Kategorie:
Phosphoglycerate Dehydrogenase (PHGDH)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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