PHGDH-IN-5 (Compound B12) is a covalen inhibitor of PHGDH with an IC50 value of 0.29 µM. PHGDH-IN-5 can inhibit cell proliferation in cancer cell lines overexpressing PHGDH. PHGDH-IN-5 can reduce the production of serine derived from glucose in MDA-MB-468 cells[1].
Molecular Weight:
211.19
Purity:
98.12
CAS Number:
[17402-86-7]
Formula:
C8H5NO4S
Target:
Phosphoglycerate Dehydrogenase (PHGDH)
Application Notes:
MCE Product type: Reference compound1
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