PROTAC ATR degrader-2, CAS [[3010273-12-5]]

Produktübersicht

• Artikelname: PROTAC ATR degrader-2, CAS [[3010273-12-5]]
• Artikelnummer: MCE-HY-161615
• Hersteller Artikelnummer: HY-161615
• Alternativnummer: MCE-HY-161615-10MG,MCE-HY-161615-5MG,MCE-HY-161615-10MMX1ML,MCE-HY-161615-50MG,MCE-HY-161615-25MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC ATR degrader-2 is a selective ATR PROTAC degrader. PROTAC ATR degrader-2 degrades ATR in acute myeloid leukemia (AML) cells MV-4-11 and MOLM-13, with DC50 values of 22.9 nM and 34.5 nM, respectively. PROTAC ATR degrader-2 has an IC50 of 29.6 nM against ATR, and its IC50 values against ATM and PI3K are both greater than 2000 nM. PROTAC ATR degrader-2 induces apoptosis, DNA damage, and upregulates p53 expression. PROTAC ATR degrader-2 inhibits cancer cell proliferation through the kinase-independent function of ATR protein. PROTAC ATR degrader-2 is applicable to research related to acute myeloid leukemia[1].

Produkteigenschaften

• Molekulargewicht: 743.81
• Reinheit: 99.73
• CAS Nummer: [3010273-12-5]
• Formel: C40H41N9O6
• Target-Kategorie: Apoptosis,ATM/ATR,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound1