PROTAC ATR degrader-2, CAS [[3010273-12-5]]

Product Overview

• Article Name: PROTAC ATR degrader-2, CAS [[3010273-12-5]]
• Biozol Catalog Number: MCE-HY-161615
• Supplier Catalog Number: HY-161615
• Alternative Catalog Number: MCE-HY-161615-10MG,MCE-HY-161615-5MG,MCE-HY-161615-10MMX1ML,MCE-HY-161615-50MG,MCE-HY-161615-25MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

PROTAC ATR degrader-2 is a selective ATR PROTAC degrader. PROTAC ATR degrader-2 degrades ATR in acute myeloid leukemia (AML) cells MV-4-11 and MOLM-13, with DC50 values of 22.9 nM and 34.5 nM, respectively. PROTAC ATR degrader-2 has an IC50 of 29.6 nM against ATR, and its IC50 values against ATM and PI3K are both greater than 2000 nM. PROTAC ATR degrader-2 induces apoptosis, DNA damage, and upregulates p53 expression. PROTAC ATR degrader-2 inhibits cancer cell proliferation through the kinase-independent function of ATR protein. PROTAC ATR degrader-2 is applicable to research related to acute myeloid leukemia[1].

Product Properties

• Molecular Weight: 743.81
• Purity: 99.73
• CAS Number: [3010273-12-5]
• Formula: C40H41N9O6
• Target: Apoptosis,ATM/ATR,PROTACs

Application Notes

• Application Notes: MCE Product type: Reference compound1