DNDI-6174 is an orally active Leishmania cytochrome b (Qi site of cytochrome bc1 complex/complex III) inhibitor. DNDI-6174 binds to the Qi site of Leishmania cytochrome b, inhibits cytochrome bc1 complex activity in the parasites electron transport chain across promastigote and axenic amastigote stages. DNDI-6174 reduces parasite burden in rodent models, inhibits growth of various Leishmania species, drug-resistant clinical isolates, and Trypanosoma cruzi, with marginal activity against Trypanosoma brucei. DNDI-6174 can be used for the research of visceral leishmaniasis, cutaneous leishmaniasis[1].
Molekulargewicht:
307.31
Reinheit:
97.28
CAS Nummer:
[2868298-43-3]
Formel:
C16H13N5O2
Target-Kategorie:
Parasite
Anwendungsbeschreibung:
MCE Product type: Reference compound
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