(S)-PHA533533 is a CDK2 and CDK5 inhibitor with blood-brain barrier permeability, with IC50 values of 37 nM and 55 nM, respectively. (S)-PHA533533 effectively restores UBE3A expression by downregulating UBE3A-ATS and relieving the epigenetic silencing of paternal UBE3A in mature neurons. (S)-PHA533533 can be used for the research of Angelman syndrome[1].
Molekulargewicht:
338.40
Reinheit:
98.27
CAS Nummer:
[437982-89-3]
Formel:
C19H22N4O2
Target-Kategorie:
CDK,E1/E2/E3 Enzyme
Anwendungsbeschreibung:
MCE Product type: Reference compound
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