ZW-1226 is a dual Tyrosyl DNA phosphodiesterase 2 (TDP2) and Multidrug resistance-associated protein 1 (MRP1) inhibitor with IC50 values of 0.2 and 0.5 µM, respectively. ZW-1226 exhibits selectivity over other ABC transporters. ZW-1226 elevates intracellular GSH levels, and reverses MRP1-mediated drug resistance. ZW-1226 can be used for the research of leukemia, non-small-cell lung cancer, and multidrug resistant small-cell lung cancer[1][2].
Molekulargewicht:
420.42
Reinheit:
98.13
CAS Nummer:
[2351940-23-1]
Formel:
C25H16N4O3
Target-Kategorie:
P-glycoprotein
Anwendungsbeschreibung:
MCE Product type: Reference compound
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