PROTAC PD-L1 degrader-2, CAS [[2995357-09-8]] Preis auf Anfrage
Artikelnummer:
MCE-HY-162972
Hersteller Artikelnummer:
HY-162972
Alternativnummer:
MCE-HY-162972-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
PROTAC PD-L1 degrader-2 (Compound 9i) is a PROTAC degrader for PD-L1, that inhibits PD-L1 with an IC50 of 197.4 nM and exhibits an affinity with PD-L1 with a Kd of 301 nM. PROTAC PD-L1 degrader-2 promotes the internalization of PD-L1 on the cell membrane, and induces PD-L1 degradation via the synergistic effect of the proteasome and lysosomal pathways. PROTAC PD-L1 degrader-2 can activate the immune system, and exhibits antitumor efficacy in MC38 C57BL/6 mouse model[1].
Molekulargewicht:
861.31
CAS Nummer:
[2995357-09-8]
Formel:
C46H42ClFN6O8
Target-Kategorie:
PD-1/PD-L1,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
