PROTAC PD-L1 degrader-2, CAS [[2995357-09-8]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-162972
Supplier Catalog Number:
HY-162972
Alternative Catalog Number:
MCE-HY-162972-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
PROTAC PD-L1 degrader-2 (Compound 9i) is a PROTAC degrader for PD-L1, that inhibits PD-L1 with an IC50 of 197.4 nM and exhibits an affinity with PD-L1 with a Kd of 301 nM. PROTAC PD-L1 degrader-2 promotes the internalization of PD-L1 on the cell membrane, and induces PD-L1 degradation via the synergistic effect of the proteasome and lysosomal pathways. PROTAC PD-L1 degrader-2 can activate the immune system, and exhibits antitumor efficacy in MC38 C57BL/6 mouse model[1].
Molecular Weight:
861.31
CAS Number:
[2995357-09-8]
Formula:
C46H42ClFN6O8
Target:
PD-1/PD-L1,PROTACs
Application Notes:
MCE Product type: Reference compound
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