LasB-IN-1 (compound 5f) is a potent and orally active inhibitor of LasB (IC50 = 8.7 µM). LasB-IN-1 effectively attenuates elastase production and biofilm formation by P. aeruginosa while alleviating the inflammatory response through downregulating MAPK and NF-kappaB pathways. LasB-IN-1 is potential to be a novel anti-infective candidate against drug-resistant infections[1].
Molekulargewicht:
365.39
Formel:
C20H22F3NO2
Target-Kategorie:
Bacterial,Elastase,NF-kappaB,p38 MAPK
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
