LasB-IN-1 (compound 5f) is a potent and orally active inhibitor of LasB (IC50 = 8.7 µM). LasB-IN-1 effectively attenuates elastase production and biofilm formation by P. aeruginosa while alleviating the inflammatory response through downregulating MAPK and NF-kappaB pathways. LasB-IN-1 is potential to be a novel anti-infective candidate against drug-resistant infections[1].
Molecular Weight:
365.39
Formula:
C20H22F3NO2
Target:
Bacterial,Elastase,NF-kappaB,p38 MAPK
Application Notes:
MCE Product type: Reference compound
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