Antitumor agent-171 (Compound 35) is an inhibitor for beta-catenin/BCL9 interaction with IC50 of 1.61 µM. Antitumor agent-171 exhibits high affinity to beta-catenin with Kd of 0.63 µM. Antitumor agent-171 inhibits the gene expression of axin2 with IC50 of 0.84 µM. Antitumor agent-171 inhibits cell viability of HCT116 with IC50 of 4.39 µM. Antitumor agent-171 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models[1].
Molekulargewicht:
643.78
Reinheit:
98.48
CAS Nummer:
[3003004-76-7]
Formel:
C35H45N7O5
Target-Kategorie:
beta-catenin
Anwendungsbeschreibung:
Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten