Antitumor agent-171 (Compound 35) is an inhibitor for beta-catenin/BCL9 interaction with IC50 of 1.61 µM. Antitumor agent-171 exhibits high affinity to beta-catenin with Kd of 0.63 µM. Antitumor agent-171 inhibits the gene expression of axin2 with IC50 of 0.84 µM. Antitumor agent-171 inhibits cell viability of HCT116 with IC50 of 4.39 µM. Antitumor agent-171 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models[1].
Molecular Weight:
643.78
Purity:
98.48
CAS Number:
[3003004-76-7]
Formula:
C35H45N7O5
Target:
beta-catenin
Application Notes:
MCE Product type: Reference compound
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