LL-K12-18 is a two-site molecular glue that enhances the protein-protein interaction of the CDK12-DDB1 complex, stabilizing the CDK12-DDB1 complex and promoting the degradation of cyclin K (EC50=0.37 nM). LL-K12-18 exhibits strong gene transcription inhibition and anti-proliferation effects in tumor cells. LL-K12-18 can be used in cancer research[1].
Molekulargewicht:
559.49
Reinheit:
98.42
Formel:
C25H32Cl2N10O
Target-Kategorie:
CDK,Molecular Glues
Anwendungsbeschreibung:
Reference compound
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