TNF-alpha-IN-18 (Compound 61) is an inhibitor for TNF-alpha (IC50 of 1.8 µM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-alpha-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC50 >50 µM. TNF-alpha-IN-18 ameliorates the TNF- or Lipopolysaccharide (HY-D1056)-induced sepsis in mouse models. TNF-alpha-IN-18 protects mice from rheumatoid arthritis[1].
Molekulargewicht:
336.67
Reinheit:
98.94
CAS Nummer:
[1272322-42-5]
Formel:
C16H7ClF2O4
Target-Kategorie:
NF-kappaB,TNF Receptor
Anwendungsbeschreibung:
Reference compound
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