STAT3-IN-32, CAS [[2591440-71-8]] Preis auf Anfrage
Artikelnummer:
MCE-HY-164445
Hersteller Artikelnummer:
HY-164445
Alternativnummer:
MCE-HY-164445-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
STAT3-IN-32 (compound 2p) is an orally active, potent STAT3 dual phosphorylation inhibitor with an indole-containing tetra-aromatic heterocycle scaffold. STAT3-IN-32 exhibits STAT3 luciferase inhibition activity using HEK293T cells with an IC50 of 5.3 nM and ATP production inhibition activity using BxPC-3 cells with an IC50 of 4.2 nM. STAT3-IN-32 significantly blocks p-Tyr705 and p-Ser727 and causes the abrogation of the corresponding nuclear transcription and mitochondrial oxidative phosphorylation functions of STAT3 by targeting the STAT3 SH2 domain (KD=21.3 nM). STAT3-IN-32 exhibits significant suppressive effects in a pancreatic cancer xenograft model[1].
Molekulargewicht:
699.68
CAS Nummer:
[2591440-71-8]
Formel:
C36H32F3N7O5
Target-Kategorie:
STAT
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
