STAT3-IN-32, CAS [[2591440-71-8]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-164445
Supplier Catalog Number:
HY-164445
Alternative Catalog Number:
MCE-HY-164445-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
STAT3-IN-32 (compound 2p) is an orally active, potent STAT3 dual phosphorylation inhibitor with an indole-containing tetra-aromatic heterocycle scaffold. STAT3-IN-32 exhibits STAT3 luciferase inhibition activity using HEK293T cells with an IC50 of 5.3 nM and ATP production inhibition activity using BxPC-3 cells with an IC50 of 4.2 nM. STAT3-IN-32 significantly blocks p-Tyr705 and p-Ser727 and causes the abrogation of the corresponding nuclear transcription and mitochondrial oxidative phosphorylation functions of STAT3 by targeting the STAT3 SH2 domain (KD=21.3 nM). STAT3-IN-32 exhibits significant suppressive effects in a pancreatic cancer xenograft model[1].
Molecular Weight:
699.68
CAS Number:
[2591440-71-8]
Formula:
C36H32F3N7O5
Target:
STAT
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
