ONC213 is an orally active alphaKGDH inhibitor. ONC213 can suppress mitochondrial respiration and elevate alpha-ketoglutarate levels by inhibiting alphaKGDH activity. ONC213 can induce cells apoptosis by inducing mitochondrial stress response and inhibiting translation of MCL-1. ONC213 can be used for the research of cancer, such as acute myeloid leukemia research (AML)[1].
Molekulargewicht:
408.44
Reinheit:
99.89
CAS Nummer:
[1977540-13-8]
Formel:
C23H22F2N4O
Target-Kategorie:
Apoptosis,Caspase,Mitochondrial Metabolism,PARP
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten