ONC213 is an orally active alphaKGDH inhibitor. ONC213 can suppress mitochondrial respiration and elevate alpha-ketoglutarate levels by inhibiting alphaKGDH activity. ONC213 can induce cells apoptosis by inducing mitochondrial stress response and inhibiting translation of MCL-1. ONC213 can be used for the research of cancer, such as acute myeloid leukemia research (AML)[1].
Molecular Weight:
408.44
Purity:
99.89
CAS Number:
[1977540-13-8]
Formula:
C23H22F2N4O
Target:
Apoptosis,Caspase,Mitochondrial Metabolism,PARP
Application Notes:
MCE Product type: Reference compound
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