L1BC8 (compound 13a) is a BRD4 PROTAC degrader with anticancer effects. L1BC8 is also a drug-linker conjugate for ADC that can be used for the synthesis of ADCs. The resulting BRD4-degrader antibody conjugates exhibit potent and antigen-dependent BRD4 degradation and antiproliferation activities in cell-based experiments. (Pink: BRD4 ligand (HY-129939), Blue: VHL ligand (HY-125845), Black: linker (HY-171663))[1].
Molekulargewicht:
1745.92
Reinheit:
99.20
CAS Nummer:
[2417370-68-2]
Formel:
C86H98F2N16O18S2
Target-Kategorie:
Drug-Linker Conjugates for ADC,Epigenetic Reader Domain,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
