L1BC8 (compound 13a) is a BRD4 PROTAC degrader with anticancer effects. L1BC8 is also a drug-linker conjugate for ADC that can be used for the synthesis of ADCs. The resulting BRD4-degrader antibody conjugates exhibit potent and antigen-dependent BRD4 degradation and antiproliferation activities in cell-based experiments. (Pink: BRD4 ligand (HY-129939), Blue: VHL ligand (HY-125845), Black: linker (HY-171663))[1].
Molecular Weight:
1745.92
Purity:
99.20
CAS Number:
[2417370-68-2]
Formula:
C86H98F2N16O18S2
Target:
Drug-Linker Conjugates for ADC,Epigenetic Reader Domain,PROTACs
Application Notes:
MCE Product type: Reference compound1
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