SCH-900875 is an orally effective CXCR3 receptor inhibitor with a pKi of 8.4. SCH-900875 blocks the activities of chemokines CXCL9, CXCL10 and CXCL11 on CXCR3, thereby inhibiting hCXCR3-mediated chemotaxis. SCH-900875 exhibits efficacy in various autoimmune and inflammatory disease models. Unexpected thrombocytopenia and aplastic hemolytic anemia with acanthocytosis are observed in long-term high-dose studies of SCH-900875[1][2].
Molekulargewicht:
553.10
Reinheit:
98.16
CAS Nummer:
[907206-98-8]
Formel:
C28H37ClN8O2
Target-Kategorie:
Arrestin,CXCR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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