SCH-900875 is an orally active, brain-penetrant and selective CXCR3 receptor inhibitor, which also shows high selectivity over CXCR1 and CXCR2 receptors. SCH-900875 binds to CXCR3, blocking the binding of ligands CXCL9, CXCL10, and CXCL11, inhibiting downstream G protein and beta-arrestin signaling pathways to suppress inflammatory cell migration. SCH-900875 is promising for research of autoimmune diseases (rheumatoid arthritis, multiple sclerosis) and inflammatory disorders (psoriasis, inflammatory bowel disease)[1][2].
Molecular Weight:
553.10
Purity:
98.16
CAS Number:
[907206-98-8]
Formula:
C28H37ClN8O2
Target:
Arrestin,CXCR
Application Notes:
MCE Product type: Reference compound
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