GSK 1842799 (TFA), CAS [[1005407-76-0]] Preis auf Anfrage
Artikelnummer:
MCE-HY-16622A
Hersteller Artikelnummer:
HY-16622A
Alternativnummer:
MCE-HY-16622A-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
GSK1842799, an alkyl-substituted biaryl amino alcohol, is a selective S1P1 modulator developed for multiple sclerosis (MS). Upon phosphorylation, GSK1842799-P exhibited subnanomolar S1P1 agonist activity with over 1000-fold selectivity over S1P3. The compound showed good oral bioavailability, rapid in vivo conversion to GSK1842799-P, and significant lymphocyte count reduction at 0.1 mg/kg. It matched FTY720 efficacy at 3 mg/kg in the mouse EAE model and achieved comparable plasma levels to FTY-720 phosphate in cynomolgus monkeys. With favorable ADME, PK/PD properties, and toxicology, GSK1842799 advanced to further clinical development[1].
Molekulargewicht:
659.56
CAS Nummer:
[1005407-76-0]
Formel:
C24H30F9N3O6S
Target-Kategorie:
LPL Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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