GSK 1842799 (TFA), CAS [[1005407-76-0]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-16622A
Supplier Catalog Number:
HY-16622A
Alternative Catalog Number:
MCE-HY-16622A-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
GSK1842799, an alkyl-substituted biaryl amino alcohol, is a selective S1P1 modulator developed for multiple sclerosis (MS). Upon phosphorylation, GSK1842799-P exhibited subnanomolar S1P1 agonist activity with over 1000-fold selectivity over S1P3. The compound showed good oral bioavailability, rapid in vivo conversion to GSK1842799-P, and significant lymphocyte count reduction at 0.1 mg/kg. It matched FTY720 efficacy at 3 mg/kg in the mouse EAE model and achieved comparable plasma levels to FTY-720 phosphate in cynomolgus monkeys. With favorable ADME, PK/PD properties, and toxicology, GSK1842799 advanced to further clinical development[1].
Molecular Weight:
659.56
CAS Number:
[1005407-76-0]
Formula:
C24H30F9N3O6S
Target:
LPL Receptor
Application Notes:
MCE Product type: Reference compound
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