LDN-214117 is an orally active ALK2 inhibitor with well-tolerated and good brain penetration. LDN-214117 has a high selectivity and low cytotoxicity for ALK2 with an IC50 value of 24 nM. LDN-214117 also is a specific bone morphogenetic proteins (BMPs) signaling inhibitor and has relatively selective inhibition for BMP6 with an IC50 value of 100 nM. LDN-214117 can be used for the research of fibrodysplasia ossificans progressiva (FOP), diffuse intrinsic pontine glioma (DIPG) [1][2].
Molekulargewicht:
419.52
Reinheit:
99.54
CAS Nummer:
[1627503-67-6]
Formel:
C25H29N3O3
Target-Kategorie:
TGF-beta Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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