OBHSA is a selective estrogen receptor (ERalpha) degrader. OBHSA blocks the cell cycle by degrading cyclin D1, thereby overcoming Tamoxifen (HY-13757A) resistance. OBHSA also triggers excessive activation of the unfolded protein response (UPR) by inducing an increase in intracellular reactive oxygen species, ultimately leading to cell apoptosis. In addition, OBHSA can also be used as an ERalpha ligand to synthesize PROTAC degraders[1][2].
Molekulargewicht:
547.54
CAS Nummer:
[1404508-27-5]
Formel:
C27H24F3NO6S
Target-Kategorie:
Apoptosis,Estrogen Receptor/ERR,Ligands for Target Protein for PROTAC
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
