OBHSA is a selective estrogen receptor (ERalpha) degrader. OBHSA blocks the cell cycle by degrading cyclin D1, thereby overcoming Tamoxifen (HY-13757A) resistance. OBHSA also triggers excessive activation of the unfolded protein response (UPR) by inducing an increase in intracellular reactive oxygen species, ultimately leading to cell apoptosis. In addition, OBHSA can also be used as an ERalpha ligand to synthesize PROTAC degraders[1][2].
Molecular Weight:
547.54
CAS Number:
[1404508-27-5]
Formula:
C27H24F3NO6S
Target:
Apoptosis,Estrogen Receptor/ERR,Ligands for Target Protein for PROTAC
Application Notes:
MCE Product type: Reference compound
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