PROTAC YAP degrader-1, CAS [[3058483-58-9]]

Produktübersicht

• Artikelname: PROTAC YAP degrader-1, CAS [[3058483-58-9]]
• Artikelnummer: MCE-HY-168016
• Hersteller Artikelnummer: HY-168016
• Alternativnummer: MCE-HY-168016-100MG,MCE-HY-168016-50MG,MCE-HY-168016-5MG,MCE-HY-168016-10MMX1ML,MCE-HY-168016-10MG,MCE-HY-168016-25MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC YAP degrader-1 is a VHL-recruiting PROTAC degrader (DC50=8.2 µM) and antiproliferative agent that targets YAP. PROTAC YAP degrader-1 recruits the E3 ligase VHL and binds to VHL to form a ternary complex containing YAP. PROTAC YAP degrader-1 inhibits the nuclear localization of YAP in cancer cells, reduces YAP/TEAD-mediated transcription, and induces TAZ protein degradation. PROTAC YAP degrader-1 reduces the oncogenic activity of YAP and exerts antiproliferative effects in the Huh7 xenograft mouse model. PROTAC YAP degrader-1 can be used for the research of hepatocellular carcinoma and mesothelioma[1].

Produkteigenschaften

• Molekulargewicht: 995.19
• Reinheit: 99.77
• CAS Nummer: [3058483-58-9]
• Formel: C56H62N6O9S
• Target-Kategorie: PROTACs,YAP

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound1