PROTAC YAP degrader-1, CAS [[3058483-58-9]]

Product Overview

• Article Name: PROTAC YAP degrader-1, CAS [[3058483-58-9]]
• Biozol Catalog Number: MCE-HY-168016
• Supplier Catalog Number: HY-168016
• Alternative Catalog Number: MCE-HY-168016-100MG,MCE-HY-168016-50MG,MCE-HY-168016-5MG,MCE-HY-168016-10MMX1ML,MCE-HY-168016-10MG,MCE-HY-168016-25MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

PROTAC YAP degrader-1 is a VHL-recruiting PROTAC degrader (DC50=8.2 µM) and antiproliferative agent that targets YAP. PROTAC YAP degrader-1 recruits the E3 ligase VHL and binds to VHL to form a ternary complex containing YAP. PROTAC YAP degrader-1 inhibits the nuclear localization of YAP in cancer cells, reduces YAP/TEAD-mediated transcription, and induces TAZ protein degradation. PROTAC YAP degrader-1 reduces the oncogenic activity of YAP and exerts antiproliferative effects in the Huh7 xenograft mouse model. PROTAC YAP degrader-1 can be used for the research of hepatocellular carcinoma and mesothelioma[1].

Product Properties

• Molecular Weight: 995.19
• Purity: 99.77
• CAS Number: [3058483-58-9]
• Formula: C56H62N6O9S
• Target: PROTACs,YAP

Application Notes

• Application Notes: MCE Product type: Reference compound1