SHP2-IN-33, CAS [[2894017-46-8]] Preis auf Anfrage

Produktübersicht

• Artikelname: SHP2-IN-33, CAS [[2894017-46-8]] Preis auf Anfrage
• Artikelnummer: MCE-HY-168715
• Hersteller Artikelnummer: HY-168715
• Alternativnummer: MCE-HY-168715-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

SHP2-IN-33 (Compound D13) is an allosteric inhibitor of SHP2 with an IC50 of 1.2 µM. In cellular studies, SHP2-IN-33 demonstrates antiproliferative activity with an IC50 of 38 µM against Huh7 cells by arresting the G0/G1 cell cycle, promoting apoptosis (Apoptosis), and suppressing the MAPK signaling pathway. In an in vivo Huh7 xenograft mouse model, SHP2-IN-33 exhibits significant antitumor activity and favorable pharmacokinetics, including 54% oral bioavailability and a half-life of 10.57 hours. SHP2-IN-33 is a promising compound for studying tumor diseases associated with SHP2[1].

Produkteigenschaften

• Molekulargewicht: 384.33
• CAS Nummer: [2894017-46-8]
• Formel: C16H19Cl2N5S
• Target-Kategorie: Apoptosis,MAPKAPK2 (MK2),SHP2

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound