SHP2-IN-33, CAS [[2894017-46-8]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-168715
Supplier Catalog Number:
HY-168715
Alternative Catalog Number:
MCE-HY-168715-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
SHP2-IN-33 (Compound D13) is an allosteric inhibitor of SHP2 with an IC50 of 1.2 µM. In cellular studies, SHP2-IN-33 demonstrates antiproliferative activity with an IC50 of 38 µM against Huh7 cells by arresting the G0/G1 cell cycle, promoting apoptosis (Apoptosis), and suppressing the MAPK signaling pathway. In an in vivo Huh7 xenograft mouse model, SHP2-IN-33 exhibits significant antitumor activity and favorable pharmacokinetics, including 54% oral bioavailability and a half-life of 10.57 hours. SHP2-IN-33 is a promising compound for studying tumor diseases associated with SHP2[1].
Molecular Weight:
384.33
CAS Number:
[2894017-46-8]
Formula:
C16H19Cl2N5S
Target:
Apoptosis,MAPKAPK2 (MK2),SHP2
Application Notes:
MCE Product type: Reference compound
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