Topoisomerase I inhibitor 17, CAS [[2413582-45-1]] Preis auf Anfrage

Produktübersicht

• Artikelname: Topoisomerase I inhibitor 17, CAS [[2413582-45-1]] Preis auf Anfrage
• Artikelnummer: MCE-HY-168739
• Hersteller Artikelnummer: HY-168739
• Alternativnummer: MCE-HY-168739-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

Topoisomerase I inhibitor 17 (Compound 7h) is a Topoisomerase I (Top1) inhibitor. Topoisomerase I inhibitor 17 reduces DDX5 and reverses the locking of Top1 activity by DDX5. Topoisomerase I inhibitor 17 induces Top1-mediated DNA damage and promotes reactive oxygen species (ROS) production. Topoisomerase I inhibitor 17 induces Apoptosis (reduces antiapoptotic proteins XIAP, Bcl-2, Survivin and up-regulates pro-apoptotic proteins Bax, gammaH2AX). Topoisomerase I inhibitor 17 also blocks the progression of the G2/M checkpoint and induces cell cycle arrest. Topoisomerase I inhibitor 17 significantly inhibits colony formation and cell migration in colorectal cancer cells. Topoisomerase I inhibitor 17 effectively reduces tumors in human PDX tumor mice[1].

Produkteigenschaften

• Molekulargewicht: 516.47
• CAS Nummer: [2413582-45-1]
• Formel: C28H21FN2O7
• Target-Kategorie: Apoptosis,Bcl-2 Family,DNA/RNA Synthesis,IAP,Reactive Oxygen Species (ROS),Survivin,Topoisomerase

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound